Welcome to the website of the Computational Biology Lab

Panayiota Poirazi is the chair of the FENS-Kavli network of excellence
FENS-Kavli’s vision is to shape the future of Neuroscience by putting young researchers in the driver’s seat. We aim to improve Neuroscience in Europe through providing opportunities for young scientists, influencing science policy, and facilitating the exchange between science and society.

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About our research

Research in the CBL can be divided in two disciplines: (a) computational neuroscience, where we focus on the use of modeling techniques for characterizing the role of dendrites in learning and memory and (b) bioinformatics, where we focus on the development of methods and tools for analyzing and modeling biological data.

Computational Neuroscience Projects

We are interested in understanding how dendrites and their integrative properties contribute to learning and memory functions. Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks). We then use the models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to memory functions.

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Bioinformatics Projects

We focus on developing computational methods and tools for (a) analyzing large-scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks. Our methodological approaches include (a) novel clustering and feature selection algorithms, (b) machine learning algorithms such as artificial neural networks, hidden Markov models etc.

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Latest News

Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity

Check out our new paper on pattern separation that was just published in Hippocampus! 

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Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites

George Kastellaki's research has been published in Cell Reports under the title: "Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites". Here is the IMBB-FORTH press:

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PhD.C. Spiros Chavlis was selected to attend the CAJAL winter school in Bordeaux, France

He was also awarded with a generous financial support from The Hippocampus journal

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FENS-Kavli Network of Excellence Mentoring and PhD Thesis Prizes

During the FENS Forum 2016 in Copenhagen, the FENS Kavli Scholars honored the Best Mentor and the Best PhD thesis for the years 2014-2016. The award winners were Prof. David Attwell, Fellow of the Royal Society (University College London) and Dr. Linda Katona (University of Oxford).

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Funding